Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes

FasL-mediated cytotoxicity is one of the mechanisms that CTLs use to kill tumor cells. However, human colon carcinoma often deregulates the Fas signaling pathway to evade host cancer immune surveillance. We aimed at testing the hypothesis that novel ceramide analogs effectively modulate Fas function...

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Publicado no:Sci Rep
Main Authors: Coe, Genevieve L., Redd, Priscilla S., Paschall, Amy V., Lu, Chunwan, Gu, Lilly, Cai, Houjian, Albers, Thomas, Lebedyeva, Iryna O., Liu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973238/
https://ncbi.nlm.nih.gov/pubmed/27487939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30816
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