Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis

Liver biopsy is the current reliable way of evaluating liver fibrosis. However, no specific sera biomarker could be applied in clinical diagnosis. As the pivotal role of osteopontin (OPN) reported in numerous liver diseases, thrombin‐cleaved OPN (Thr‐OPN) exposes an integrin‐binding motif that promo...

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Publicat a:J Cell Physiol
Autors principals: Cui, Guangying, Chen, Jianing, Wu, Zhongwen, Huang, Haijun, Wang, Lin, Liang, Yan, Zeng, Ping, Yang, Jiezuan, Uede, Toshimitsu, Diao, Hongyan
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Original Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588095/
https://ncbi.nlm.nih.gov/pubmed/30350863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.27571
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