Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin

Osteopontin (OPN) is a T helper type 1 immunoregulatory cytokine that plays a critical role in various inflammatory disorders. OPN exerts proinflammatory reactions through interaction with integrin receptors. OPN function can be modulated by protease digestion. However, the molecular mechanisms that...

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Bibliografiska uppgifter
Huvudupphovsmän: Kon, Shigeyuki, Ikesue, Masahiro, Kimura, Chiemi, Aoki, Momoe, Nakayama, Yosuke, Saito, Yoshinari, Kurotaki, Daisuke, Diao, Hongyan, Matsui, Yutaka, Segawa, Tatsuya, Maeda, Masahiro, Kojima, Tetsuhito, Uede, Toshimitsu
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2008
Ämnen:
Brief Definitive Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234375/
https://ncbi.nlm.nih.gov/pubmed/18158320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071324
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