A Novel Cryptic Binding Motif, LRSKSRSFQVSDEQY, in the C-Terminal Fragment of MMP-3/7-Cleaved Osteopontin as a Novel Ligand for α9β1 Integrin Is Involved in the Anti-Type II Collagen Antibody-Induced Arthritis

Osteopontin (OPN) is a multifunctional protein that has been linked to various intractable inflammatory diseases. One way by which OPN induces inflammation is the production of various functional fragments by enzyme cleavage. It has been well appreciated that OPN is cleaved by thrombin, and/or matri...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Kon, Shigeyuki, Nakayama, Yosuke, Matsumoto, Naoki, Ito, Koyu, Kanayama, Masashi, Kimura, Chiemi, Kouro, Hitomi, Ashitomi, Dai, Matsuda, Tadashi, Uede, Toshimitsu
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278882/
https://ncbi.nlm.nih.gov/pubmed/25545242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116210
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