Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis

Liver biopsy is the current reliable way of evaluating liver fibrosis. However, no specific sera biomarker could be applied in clinical diagnosis. As the pivotal role of osteopontin (OPN) reported in numerous liver diseases, thrombin‐cleaved OPN (Thr‐OPN) exposes an integrin‐binding motif that promo...

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Veröffentlicht in:J Cell Physiol
Hauptverfasser: Cui, Guangying, Chen, Jianing, Wu, Zhongwen, Huang, Haijun, Wang, Lin, Liang, Yan, Zeng, Ping, Yang, Jiezuan, Uede, Toshimitsu, Diao, Hongyan
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Original Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588095/
https://ncbi.nlm.nih.gov/pubmed/30350863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.27571
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