Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis

Liver biopsy is the current reliable way of evaluating liver fibrosis. However, no specific sera biomarker could be applied in clinical diagnosis. As the pivotal role of osteopontin (OPN) reported in numerous liver diseases, thrombin‐cleaved OPN (Thr‐OPN) exposes an integrin‐binding motif that promo...

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Detalhes bibliográficos
Publicado no:J Cell Physiol
Main Authors: Cui, Guangying, Chen, Jianing, Wu, Zhongwen, Huang, Haijun, Wang, Lin, Liang, Yan, Zeng, Ping, Yang, Jiezuan, Uede, Toshimitsu, Diao, Hongyan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588095/
https://ncbi.nlm.nih.gov/pubmed/30350863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.27571
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