Genomic knockout of alms1 in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypes

Alström syndrome (OMIM #203800) is an autosomal recessive obesity ciliopathy caused by loss-of-function mutations in the ALMS1 gene. In addition to multi-organ dysfunction, such as cardiomyopathy, retinal degeneration and renal dysfunction, the disorder is characterized by high rates of obesity, ins...

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發表在:Hum Mol Genet
Main Authors: Nesmith, Jessica E, Hostelley, Timothy L, Leitch, Carmen C, Matern, Maggie S, Sethna, Saumil, McFarland, Rebecca, Lodh, Sukanya, Westlake, Christopher J, Hertzano, Ronna, Ahmed, Zubair M, Zaghloul, Norann A
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586141/
https://ncbi.nlm.nih.gov/pubmed/31220269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz053
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