Genomic knockout of alms1 in zebrafish recapitulates Alström syndrome and provides insight into metabolic phenotypes

Alström syndrome (OMIM #203800) is an autosomal recessive obesity ciliopathy caused by loss-of-function mutations in the ALMS1 gene. In addition to multi-organ dysfunction, such as cardiomyopathy, retinal degeneration and renal dysfunction, the disorder is characterized by high rates of obesity, ins...

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Détails bibliographiques
Publié dans:Hum Mol Genet
Auteurs principaux: Nesmith, Jessica E, Hostelley, Timothy L, Leitch, Carmen C, Matern, Maggie S, Sethna, Saumil, McFarland, Rebecca, Lodh, Sukanya, Westlake, Christopher J, Hertzano, Ronna, Ahmed, Zubair M, Zaghloul, Norann A
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
General Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6586141/
https://ncbi.nlm.nih.gov/pubmed/31220269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz053
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