C8-Substituted Imidazotetrazine Analogs Overcome Temozolomide Resistance by Inducing DNA Adducts and DNA Damage

Temozolomide (TMZ) is the standard of care chemotherapeutic agent used in the treatment of glioblastoma multiforme. Cytotoxic O6-methylguaine lesions formed by TMZ are repaired by O6-methyl-guanine DNA methyltransferase (MGMT), a DNA repair protein that removes alkyl groups located at the O6-positio...

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Dades bibliogràfiques
Publicat a:Front Oncol
Autors principals: Yang, Zhikuan, Wei, Danping, Dai, Xiaoli, Stevens, Malcolm F. G., Bradshaw, Tracey D., Luo, Ying, Zhang, Jihong
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6584802/
https://ncbi.nlm.nih.gov/pubmed/31263673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00485
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