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Chemical Biology of N(5)-Substituted Formamidopyrimidine DNA Adducts
DNA nucleobases are the prime targets for chemical modifications by endogenous and exogenous electrophiles. Alkylation of the N7 position of guanine and adenine in DNA triggers base-catalyzed imidazole ring opening and the formation of N(5)-substituted formamidopyrimidine (N(5)-R-FAPy) lesions. Me-F...
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| Publicado no: | Chem Res Toxicol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5422107/ https://ncbi.nlm.nih.gov/pubmed/27959490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00392 |
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