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Processing of N(5)-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3
A variety of agents cause DNA base alkylation damage, including the known hepatocarcinogen aflatoxin B(1) (AFB(1)) and chemotherapeutic drugs derived from nitrogen mustard (NM). The N7 site of guanine is the primary site of alkylation, with some N7-deoxyguanosine adducts undergoing imidazole ring-op...
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| Publicado no: | DNA Repair (Amst) |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6588396/ https://ncbi.nlm.nih.gov/pubmed/30448017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.11.001 |
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