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Mutagenic Spectra Arising from Replication Bypass of the 2,6-diamino-4-hydroxy-N(5)-methyl Formamidopyrimidine Adduct in Primate Cells

DNA exposures to electrophilic methylating agents that are commonly used during chemotherapeutic treatments cause diverse chemical modifications of nucleobases, with reaction at N7-dG being the most abundant. Although this base modification frequently results in destabilization of the glycosyl bond...

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Detalhes bibliográficos
Main Authors: Earley, Lauriel F., Minko, Irina G., Christov, Plamen P., Rizzo, Carmelo J., Lloyd, R. Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3830661/
https://ncbi.nlm.nih.gov/pubmed/23763662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx4001495
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