Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

The cellular responses to two new temozolomide (TMZ) analogues, DP68 and DP86, acting against glioblastoma multiforme (GBM) cell lines and primary culture models are reported. Dose-response analysis of cultured GBM cells revealed that DP68 is more potent than DP86 and TMZ and that DP68 was effective...

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Bibliographic Details
Published in:Mol Cancer Ther
Main Authors: Ramirez, Yulian P., Mladek, Ann C., Phillips, Roger M., Gynther, Mikko, Rautio, Jarkko, Ross, Alonzo H., Wheelhouse, Richard T., Sakaria, Jann N.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297195/
https://ncbi.nlm.nih.gov/pubmed/25351918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0113
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