Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma

Many conventional chemotherapeutic drugs exert their cytotoxic function by inducing DNA damage in the tumor cell. Therefore, a cell-inherent DNA repair pathway, which reverses the DNA-damaging effect of the cytotoxic drugs, can mediate therapeutic resistance to chemotherapy. The monofunctional DNA-a...

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Bibliographic Details
Main Authors: Yoshimoto, Koji, Mizoguchi, Masahiro, Hata, Nobuhiro, Murata, Hideki, Hatae, Ryusuke, Amano, Toshiyuki, Nakamizo, Akira, Sasaki, Tomio
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2012
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514620/
https://ncbi.nlm.nih.gov/pubmed/23227453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00186
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