Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

Over half of colorectal cancers (CRCs) harbor TP53 missense mutations (mutp53). We show that the most common mutp53 allele R248Q (p53(Q)) exerts gain of function (GOF) and creates tumor dependence in mouse CRC models. mutp53 protein binds Stat3 and enhances activating Stat3 phosphorylation by displa...

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Pubblicato in:Cancer Cell
Autori principali: Schulz-Heddergott, Ramona, Stark, Nadine, Edmunds, Shelley J., Li, Jinyu, Conradi, Lena-Christin, Bohnenberger, Hanibal, Ceteci, Fatih, Greten, Florian R., Dobbelstein, Matthias, Moll, Ute M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582949/
https://ncbi.nlm.nih.gov/pubmed/30107178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.07.004
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