Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

Over half of colorectal cancers (CRCs) harbor TP53 missense mutations (mutp53). We show that the most common mutp53 allele R248Q (p53(Q)) exerts gain of function (GOF) and creates tumor dependence in mouse CRC models. mutp53 protein binds Stat3 and enhances activating Stat3 phosphorylation by displa...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Schulz-Heddergott, Ramona, Stark, Nadine, Edmunds, Shelley J., Li, Jinyu, Conradi, Lena-Christin, Bohnenberger, Hanibal, Ceteci, Fatih, Greten, Florian R., Dobbelstein, Matthias, Moll, Ute M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6582949/
https://ncbi.nlm.nih.gov/pubmed/30107178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.07.004
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