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Gain-of-Function (GOF) Mutant p53 as Actionable Therapeutic Target
p53 missense mutant alleles are present in nearly 40% of all human tumors. Such mutated alleles generate aberrant proteins that not only lose their tumor-suppressive functions but also frequently act as driver oncogenes, which promote malignant progression, invasion, metastasis, and chemoresistance,...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Cancers (Basel) |
|---|---|
| Prif Awduron: | , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
MDPI
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6025530/ https://ncbi.nlm.nih.gov/pubmed/29875343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10060188 |
| Tagiau: |
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