The Gain-of-Function p53 R248W Mutant Promotes Migration by STAT3 Deregulation in Human Pancreatic Cancer Cells

Missense p53 mutations (mutp53) occur in approx. 70% of pancreatic ductal adenocarcinomas (PDAC). Typically, mutp53 proteins are aberrantly stabilized by Hsp90/Hsp70/Hsp40 chaperone complexes. Notably, stabilization is a precondition for specific mutp53 alleles to acquire powerful neomorphic oncogen...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Klemke, Luisa, Fehlau, Clara F., Winkler, Nadine, Toboll, Felicia, Singh, Shiv K., Moll, Ute M., Schulz-Heddergott, Ramona
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226097/
https://ncbi.nlm.nih.gov/pubmed/34178628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.642603
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