Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer

Macrophage migration inhibitory factor (MIF) is an upstream regulator of innate immunity, but its expression is increased in some cancers via stabilization with HSP90-associated chaperones. Here, we show that MIF stabilization is tumor-specific in an acute colitis-associated colorectal cancer (CRC)...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Klemke, Luisa, De Oliveira, Tiago, Witt, Daria, Winkler, Nadine, Bohnenberger, Hanibal, Bucala, Richard, Conradi, Lena-Christin, Schulz-Heddergott, Ramona
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862487/
https://ncbi.nlm.nih.gov/pubmed/33542244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03426-z
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