Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer

Macrophage migration inhibitory factor (MIF) is an upstream regulator of innate immunity, but its expression is increased in some cancers via stabilization with HSP90-associated chaperones. Here, we show that MIF stabilization is tumor-specific in an acute colitis-associated colorectal cancer (CRC)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Klemke, Luisa, De Oliveira, Tiago, Witt, Daria, Winkler, Nadine, Bohnenberger, Hanibal, Bucala, Richard, Conradi, Lena-Christin, Schulz-Heddergott, Ramona
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862487/
https://ncbi.nlm.nih.gov/pubmed/33542244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03426-z
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