A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine

MenB-4C (Bexsero; GlaxoSmithKline Biologicals) is a licensed meningococcal vaccine for capsular B strains. The vaccine contains detergent-extracted outer membrane vesicles (dOMV) and three recombinant proteins, of which one is factor H binding protein (FHbp). In previous studies, overexpression of F...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Beernink, Peter T., Vianzon, Vianca, Lewis, Lisa A., Moe, Gregory R., Granoff, Dan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581866/
https://ncbi.nlm.nih.gov/pubmed/31213564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01231-19
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