Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely unclear. Here, acute perturbations (~1 hr) to actomyosin stress or ECM elasticity cause rapid and reversible changes in lamin-A, DNA damage, and cell cycle. The findings are especially relevant to organs such as...

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Pubblicato in:Dev Cell
Autori principali: Cho, Sangkyun, Vashisth, Manasvita, Abbas, Amal, Majkut, Stephanie, Vogel, Kenneth, Xia, Yuntao, Ivanovska, Irena L., Irianto, Jerome, Tewari, Manorama, Zhu, Kuangzheng, Tichy, Elisia D., Mourkioti, Foteini, Tang, Hsin-Yao, Greenberg, Roger A., Prosser, Benjamin L., Discher, Dennis E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581604/
https://ncbi.nlm.nih.gov/pubmed/31105008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.04.020
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