Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

Whether cell forces or extracellular matrix (ECM) can impact genome integrity is largely unclear. Here, acute perturbations (~1 hr) to actomyosin stress or ECM elasticity cause rapid and reversible changes in lamin-A, DNA damage, and cell cycle. The findings are especially relevant to organs such as...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Dev Cell
Main Authors: Cho, Sangkyun, Vashisth, Manasvita, Abbas, Amal, Majkut, Stephanie, Vogel, Kenneth, Xia, Yuntao, Ivanovska, Irena L., Irianto, Jerome, Tewari, Manorama, Zhu, Kuangzheng, Tichy, Elisia D., Mourkioti, Foteini, Tang, Hsin-Yao, Greenberg, Roger A., Prosser, Benjamin L., Discher, Dennis E.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581604/
https://ncbi.nlm.nih.gov/pubmed/31105008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.04.020
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki