Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

Administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mammals causes damage to the nigrostriatal dopaminergic pathway similar to that observed in Parkinson's disease. It has been suggested that the mechanism by which MPTP kills dopamine (DA) neurons involves an energy crisis...

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Publicado en:J Neurosci
Main Authors: Przedborski, S, Kostic, V, Jackson-Lewis, V, Naini, AB, Simonetti, S, Fahn, S, Carlson, E, Epstein, CJ, Cadet, JL
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 1992
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575882/
https://ncbi.nlm.nih.gov/pubmed/1578260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.12-05-01658.1992
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