Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity

Administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mammals causes damage to the nigrostriatal dopaminergic pathway similar to that observed in Parkinson's disease. It has been suggested that the mechanism by which MPTP kills dopamine (DA) neurons involves an energy crisis...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Przedborski, S, Kostic, V, Jackson-Lewis, V, Naini, AB, Simonetti, S, Fahn, S, Carlson, E, Epstein, CJ, Cadet, JL
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1992
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6575882/
https://ncbi.nlm.nih.gov/pubmed/1578260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.12-05-01658.1992
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