Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent dopaminergic neurotoxin that causes biochemical, pharmacological, and pathological deficits in experimental animals similar to those seen in human parkinsonian patients. All of the deficits can be prevented by treating mice with selecti...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Heikkila, R E, Kindt, M V, Sonsalla, P K, Giovanni, A, Youngster, S K, McKeown, K A, Singer, T P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281927/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3137566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.16.6172
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