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Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent dopaminergic neurotoxin that causes biochemical, pharmacological, and pathological deficits in experimental animals similar to those seen in human parkinsonian patients. All of the deficits can be prevented by treating mice with selecti...

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Bibliografische gegevens
Hoofdauteurs: Heikkila, R E, Kindt, M V, Sonsalla, P K, Giovanni, A, Youngster, S K, McKeown, K A, Singer, T P
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1988
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC281927/
https://ncbi.nlm.nih.gov/pubmed/3137566
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