Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent dopaminergic neurotoxin that causes biochemical, pharmacological, and pathological deficits in experimental animals similar to those seen in human parkinsonian patients. All of the deficits can be prevented by treating mice with selecti...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Heikkila, R E, Kindt, M V, Sonsalla, P K, Giovanni, A, Youngster, S K, McKeown, K A, Singer, T P
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1988
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281927/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3137566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.16.6172
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