Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent dopaminergic neurotoxin that causes biochemical, pharmacological, and pathological deficits in experimental animals similar to those seen in human parkinsonian patients. All of the deficits can be prevented by treating mice with selecti...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Heikkila, R E, Kindt, M V, Sonsalla, P K, Giovanni, A, Youngster, S K, McKeown, K A, Singer, T P
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1988
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281927/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3137566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.16.6172
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