Importance of monoamine oxidase A in the bioactivation of neurotoxic analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a potent dopaminergic neurotoxin that causes biochemical, pharmacological, and pathological deficits in experimental animals similar to those seen in human parkinsonian patients. All of the deficits can be prevented by treating mice with selecti...

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Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Heikkila, R E, Kindt, M V, Sonsalla, P K, Giovanni, A, Youngster, S K, McKeown, K A, Singer, T P
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1988
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281927/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3137566/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.16.6172
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