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Deconstructing the Polymerase Chain Reaction II: an improved workflow and effects on artifact formation and primer degeneracy

Polymerase chain reaction (PCR) amplification of complex microbial genomic DNA templates with degenerate primers can lead to distortion of the underlying community structure due to inefficient primer-template interactions leading to bias. We previously described a method of deconstructed PCR (“PEX P...

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Bibliografski detalji
Izdano u:PeerJ
Glavni autori: Naqib, Ankur, Poggi, Silvana, Green, Stefan J.
Format: Artigo
Jezik:Inglês
Izdano: PeerJ Inc. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573857/
https://ncbi.nlm.nih.gov/pubmed/31231597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.7121
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