Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

The PDAPP transgenic mouse overexpresses human amyloid precursor protein V717F (PDAPP minigene) and develops age-related cerebral amyloid-β protein (Aβ) deposits similar to senile plaques in Alzheimer’s disease. We find age-related cortical and limbic Aβ deposition that begins at 8 months and progre...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Irizarry, Michael C., Soriano, Ferdie, McNamara, Megan, Page, Keith J., Schenk, Dale, Games, Dora, Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 1997
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573263/
https://ncbi.nlm.nih.gov/pubmed/9278541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-18-07053.1997
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