Active β-Amyloid Immunization Restores Spatial Learning in PDAPP Mice Displaying Very Low Levels of β-Amyloid

The behavioral and biochemical impact of active immunization against human β-amyloid (Aβ) was assessed using male transgenic (Tg) mice overexpressing a human mutant amyloid precursor protein (heterozygous PDAPP mice) and littermate controls. Administration of aggregated Aβ(42) occurred at monthly in...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Chen, Guiquan, Chen, Karen S., Kobayashi, Dione, Barbour, Robin, Motter, Ruth, Games, Dora, Martin, Stephen J., Morris, Richard G. M.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6672499/
https://ncbi.nlm.nih.gov/pubmed/17344403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3710-06.2007
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