Exosomes from CD99-deprived Ewing sarcoma cells reverse tumor malignancy by inhibiting cell migration and promoting neural differentiation

Ewing sarcoma (EWS) is an aggressive mesenchymal tumor with unmet clinical need and significant social impacts on children, adolescents, and young adults. CD99, a hallmark surface molecule of EWS, participates in crucial biological processes including cell migration, differentiation, and death. EWS...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: De Feo, Alessandra, Sciandra, Marika, Ferracin, Manuela, Felicetti, Federica, Astolfi, Annalisa, Pignochino, Ymera, Picci, Piero, Carè, Alessandra, Scotlandi, Katia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6572819/
https://ncbi.nlm.nih.gov/pubmed/31209202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1675-1
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