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Cruzain structures: apocruzain and cruzain bound to S-methyl thiomethanesulfonate and implications for drug design

Chagas disease, which is caused by Trypanosoma cruzi, affects more than six million people worldwide. Cruzain is the major cysteine protease involved in the survival of this parasite. Here, the expression, purification and crystallization of this enzyme are reported. The cruzain crystals diffracted...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Crystallogr F Struct Biol Commun
Prif Awduron: Barbosa da Silva, Elany, Dall, Elfriede, Briza, Peter, Brandstetter, Hans, Ferreira, Rafaela Salgado
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: International Union of Crystallography 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6572096/
https://ncbi.nlm.nih.gov/pubmed/31204688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19006320
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