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Cruzain structures: apocruzain and cruzain bound to S-methyl thiomethanesulfonate and implications for drug design
Chagas disease, which is caused by Trypanosoma cruzi, affects more than six million people worldwide. Cruzain is the major cysteine protease involved in the survival of this parasite. Here, the expression, purification and crystallization of this enzyme are reported. The cruzain crystals diffracted...
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| Publicado no: | Acta Crystallogr F Struct Biol Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6572096/ https://ncbi.nlm.nih.gov/pubmed/31204688 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19006320 |
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