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Protease recognition sites in Bet v 1a are cryptic, explaining its slow processing relevant to its allergenicity

Despite a high similarity with homologous protein families, only few proteins trigger an allergic immune response with characteristic T(H)2 polarization. This puzzling observation is illustrated by the major birch pollen allergen Bet v 1a and its hypoallergenic protein isoforms, e.g., Bet v 1d. Give...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Freier, Regina, Dall, Elfriede, Brandstetter, Hans
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522599/
https://ncbi.nlm.nih.gov/pubmed/26235974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12707
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