Stabilization of the Dimeric Birch Pollen Allergen Bet v 1 Impacts Its Immunological Properties

Many allergens share several biophysical characteristics, including the capability to undergo oligomerization. The dimerization mechanism in Bet v 1 and its allergenic properties are so far poorly understood. Here, we report crystal structures of dimeric Bet v 1, revealing a noncanonical incorporati...

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Hlavní autoři: Kofler, Stefan, Ackaert, Chloé, Samonig, Martin, Asam, Claudia, Briza, Peter, Horejs-Hoeck, Jutta, Cabrele, Chiara, Ferreira, Fatima, Duschl, Albert, Huber, Christian, Brandstetter, Hans
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3879576/
https://ncbi.nlm.nih.gov/pubmed/24253036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.518795
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