The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension

Mutations in superoxide dismutase 1 (SOD1) cause amyotrophic lateral sclerosis (ALS). Disease pathogenesis is linked to destabilization, disorder and aggregation of the SOD1 protein. However, the non-genetic factors that promote disorder and the subsequent aggregation of SOD1 have not been studied....

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Опубликовано в: :Acta Neuropathol
Главные авторы: Keskin, Isil, Forsgren, Elin, Lehmann, Manuela, Andersen, Peter M., Brännström, Thomas, Lange, Dale J., Synofzik, Matthis, Nordström, Ulrika, Zetterström, Per, Marklund, Stefan L., Gilthorpe, Jonathan D.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2019
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Original Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570705/
https://ncbi.nlm.nih.gov/pubmed/30863976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-01986-1
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