Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients

Mutations in superoxide dismutase-1 (SOD1) are a common known cause of amyotrophic lateral sclerosis (ALS). The neurotoxicity of mutant SOD1s is most likely caused by misfolded molecular species, but disease pathogenesis is still not understood. Proposed mechanisms include impaired mitochondrial fun...

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Pubblicato in:PLoS One
Autori principali: Keskin, Isil, Forsgren, Elin, Lange, Dale J., Weber, Markus, Birve, Anna, Synofzik, Matthis, Gilthorpe, Jonathan D., Andersen, Peter M., Marklund, Stefan L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769150/
https://ncbi.nlm.nih.gov/pubmed/26919046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150133
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