Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients

Mutations in superoxide dismutase-1 (SOD1) are a common known cause of amyotrophic lateral sclerosis (ALS). The neurotoxicity of mutant SOD1s is most likely caused by misfolded molecular species, but disease pathogenesis is still not understood. Proposed mechanisms include impaired mitochondrial fun...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Keskin, Isil, Forsgren, Elin, Lange, Dale J., Weber, Markus, Birve, Anna, Synofzik, Matthis, Gilthorpe, Jonathan D., Andersen, Peter M., Marklund, Stefan L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769150/
https://ncbi.nlm.nih.gov/pubmed/26919046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150133
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares