Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients

Mutations in superoxide dismutase-1 (SOD1) are a common known cause of amyotrophic lateral sclerosis (ALS). The neurotoxicity of mutant SOD1s is most likely caused by misfolded molecular species, but disease pathogenesis is still not understood. Proposed mechanisms include impaired mitochondrial fun...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Keskin, Isil, Forsgren, Elin, Lange, Dale J., Weber, Markus, Birve, Anna, Synofzik, Matthis, Gilthorpe, Jonathan D., Andersen, Peter M., Marklund, Stefan L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769150/
https://ncbi.nlm.nih.gov/pubmed/26919046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150133
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