Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients

Mutations in superoxide dismutase-1 (SOD1) are a common known cause of amyotrophic lateral sclerosis (ALS). The neurotoxicity of mutant SOD1s is most likely caused by misfolded molecular species, but disease pathogenesis is still not understood. Proposed mechanisms include impaired mitochondrial fun...

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Udgivet i:PLoS One
Main Authors: Keskin, Isil, Forsgren, Elin, Lange, Dale J., Weber, Markus, Birve, Anna, Synofzik, Matthis, Gilthorpe, Jonathan D., Andersen, Peter M., Marklund, Stefan L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769150/
https://ncbi.nlm.nih.gov/pubmed/26919046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150133
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