Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context

DNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired to ensure genomic stability and avoid cell death. The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex that has structural and catalytic functions. Further...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Casari, Erika, Rinaldi, Carlo, Marsella, Antonio, Gnugnoli, Marco, Colombo, Chiara Vittoria, Bonetti, Diego, Longhese, Maria Pia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6567933/
https://ncbi.nlm.nih.gov/pubmed/31231660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00043
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