Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors

Background. The KEAP1/NRF2 pathway has been widely investigated in tumors since it was implicated in cancer cells survival and therapies resistance. In lung tumors the deregulation of this pathway is mainly related to point mutations of KEAP1 and NFE2L2 genes and KEAP1 promoter hypermethylation, but...

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Published in:Int J Mol Sci
Main Authors: Sparaneo, Angelo, Fabrizio, Federico Pio, la Torre, Annamaria, Graziano, Paolo, Di Maio, Massimo, Fontana, Andrea, Bisceglia, Michele, Rossi, Antonio, Pizzolitto, Stefano, De Maglio, Giovanna, Tancredi, Antonio, Grimaldi, Franco, Balsamo, Teresa, Centra, Flavia, Manzorra, Maria Carmina, Trombetta, Domenico, Pantalone, Angela, Bonfitto, Antonio, Maiello, Evaristo, Fazio, Vito Michele, Muscarella, Lucia Anna
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566555/
https://ncbi.nlm.nih.gov/pubmed/31126053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102531
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