Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors

Background. The KEAP1/NRF2 pathway has been widely investigated in tumors since it was implicated in cancer cells survival and therapies resistance. In lung tumors the deregulation of this pathway is mainly related to point mutations of KEAP1 and NFE2L2 genes and KEAP1 promoter hypermethylation, but...

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發表在:Int J Mol Sci
Main Authors: Sparaneo, Angelo, Fabrizio, Federico Pio, la Torre, Annamaria, Graziano, Paolo, Di Maio, Massimo, Fontana, Andrea, Bisceglia, Michele, Rossi, Antonio, Pizzolitto, Stefano, De Maglio, Giovanna, Tancredi, Antonio, Grimaldi, Franco, Balsamo, Teresa, Centra, Flavia, Manzorra, Maria Carmina, Trombetta, Domenico, Pantalone, Angela, Bonfitto, Antonio, Maiello, Evaristo, Fazio, Vito Michele, Muscarella, Lucia Anna
格式: Artigo
語言:Inglês
出版: MDPI 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566555/
https://ncbi.nlm.nih.gov/pubmed/31126053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102531
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