Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors

Background. The KEAP1/NRF2 pathway has been widely investigated in tumors since it was implicated in cancer cells survival and therapies resistance. In lung tumors the deregulation of this pathway is mainly related to point mutations of KEAP1 and NFE2L2 genes and KEAP1 promoter hypermethylation, but...

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Detaylı Bibliyografya
Yayımlandı:Int J Mol Sci
Asıl Yazarlar: Sparaneo, Angelo, Fabrizio, Federico Pio, la Torre, Annamaria, Graziano, Paolo, Di Maio, Massimo, Fontana, Andrea, Bisceglia, Michele, Rossi, Antonio, Pizzolitto, Stefano, De Maglio, Giovanna, Tancredi, Antonio, Grimaldi, Franco, Balsamo, Teresa, Centra, Flavia, Manzorra, Maria Carmina, Trombetta, Domenico, Pantalone, Angela, Bonfitto, Antonio, Maiello, Evaristo, Fazio, Vito Michele, Muscarella, Lucia Anna
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566555/
https://ncbi.nlm.nih.gov/pubmed/31126053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20102531
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