Frequent NRG1 fusions in Caucasian pulmonary mucinous adenocarcinoma predicted by Phospho-ErbB3 expression

NRG1 fusions were recently reported as a new molecular feature of Invasive Mucinous Adenocarcinoma (IMA) of the lung. The NRG1 chimeric ligand acts as a strong inductor of phosphorylation and tyrosine kinase activity of the ErbB2/ErbB3 heterodimer, thus enhancing the PI3K–AKT/MAPK pathways. The NRG1...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Trombetta, Domenico, Graziano, Paolo, Scarpa, Aldo, Sparaneo, Angelo, Rossi, Giulio, Rossi, Antonio, Di Maio, Massimo, Antonello, Davide, Mafficini, Andrea, Fabrizio, Federico Pio, Manzorra, Maria Carmina, Balsamo, Teresa, Centra, Flavia, Simbolo, Michele, Pantalone, Angela, Notarangelo, Michela, Parente, Paola, Lucia Dimitri, Maria Cecilia, Bonfitto, Antonio, Fiordelisi, Fabiola, Storlazzi, Clelia Tiziana, L'Abbate, Alberto, Taurchini, Marco, Maiello, Evaristo, Fazio, Vito Michele, Muscarella, Lucia Anna
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2018
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839392/
https://ncbi.nlm.nih.gov/pubmed/29515761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23800
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