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Targeting extracellular glycans: tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis

Innovative chemotherapeutic agents that are active against Mycobacterium tuberculosis (Mtb) are urgently required to control the tuberculosis (TB) epidemic. The Mtb cell envelope has distinct (lipo)polysaccharides and glycolipids that play a critical role in Mtb survival and pathogenesis and disrupt...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Guy, Collette S., Gibson, Matthew I., Fullam, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566077/
https://ncbi.nlm.nih.gov/pubmed/31360399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc00415g
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