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Targeting virulence: salmochelin modification tunes the antibacterial activity spectrum of β-lactams for pathogen-selective killing of Escherichia coli

New antibiotics are required to treat bacterial infections and counteract the emergence of antibiotic resistance. Pathogen-specific antibiotics have several advantages over broad-spectrum drugs, which include minimal perturbation to the commensal microbiota. We present a strategy for targeting antib...

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Vydáno v:Chem Sci
Hlavní autoři: Chairatana, Phoom, Zheng, Tengfei, Nolan, Elizabeth M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499518/
https://ncbi.nlm.nih.gov/pubmed/28717471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc00962f
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