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A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS
The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) is a key Ras activator that is autoinhibited in the cytosol and activates upon membrane recruitment. Autoinhibition release involves structural rearrangements of the protein at the membrane and thus introduces a delay between initia...
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| Publicado en: | Science |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6563836/ https://ncbi.nlm.nih.gov/pubmed/30846600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau5721 |
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