A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) is a key Ras activator that is autoinhibited in the cytosol and activates upon membrane recruitment. Autoinhibition release involves structural rearrangements of the protein at the membrane and thus introduces a delay between initia...

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Bibliographic Details
Published in:Science
Main Authors: Huang, William Y. C., Alvarez, Steven, Kondo, Yasushi, Lee, Young Kwang, Chung, Jean K., Lam, Hiu Yue Monatrice, Biswas, Kabir H., Kuriyan, John, Groves, Jay T.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563836/
https://ncbi.nlm.nih.gov/pubmed/30846600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aau5721
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