Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

IMPORTANCE: Previous genome-wide association studies of common variants identified associations for Alzheimer disease (AD) loci evident only among individuals with particular APOE alleles. OBJECTIVE: To identify APOE genotype-dependent associations with infrequent and rare variants using whole-exome...

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Udgivet i:JAMA Neurol
Main Authors: Ma, Yiyi, Jun, Gyungah R., Zhang, Xiaoling, Chung, Jaeyoon, Naj, Adam C., Chen, Yuning, Bellenguez, Celine, Hamilton-Nelson, Kara, Martin, Eden R., Kunkle, Brian W., Bis, Joshua C., Debette, Stéphanie, DeStefano, Anita L., Fornage, Myriam, Nicolas, Gaël, van Duijn, Cornelia, Bennett, David A., De Jager, Philip L., Mayeux, Richard, Haines, Jonathan L, Pericak-Vance, Margaret A., Seshadri, Sudha, Lambert, Jean-Charles, Schellenberg, Gerard D., Lunetta, Kathryn L., Farrer, Lindsay A.
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2019
Fag:
Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563544/
https://ncbi.nlm.nih.gov/pubmed/31180460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.1456
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