Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

IMPORTANCE: Previous genome-wide association studies of common variants identified associations for Alzheimer disease (AD) loci evident only among individuals with particular APOE alleles. OBJECTIVE: To identify APOE genotype-dependent associations with infrequent and rare variants using whole-exome...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Ma, Yiyi, Jun, Gyungah R., Zhang, Xiaoling, Chung, Jaeyoon, Naj, Adam C., Chen, Yuning, Bellenguez, Celine, Hamilton-Nelson, Kara, Martin, Eden R., Kunkle, Brian W., Bis, Joshua C., Debette, Stéphanie, DeStefano, Anita L., Fornage, Myriam, Nicolas, Gaël, van Duijn, Cornelia, Bennett, David A., De Jager, Philip L., Mayeux, Richard, Haines, Jonathan L, Pericak-Vance, Margaret A., Seshadri, Sudha, Lambert, Jean-Charles, Schellenberg, Gerard D., Lunetta, Kathryn L., Farrer, Lindsay A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563544/
https://ncbi.nlm.nih.gov/pubmed/31180460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.1456
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